Two boys in this photograph from the early 1900s, taken by Dr. Allan Warner of the Isolation Hospital in Leicester

Two boys in this photograph from the early 1900s, taken by Dr. Allan Warner of the Isolation Hospital in Leicester, UK, had been exposed to the same source of smallpox.

One of them had received the smallpox vaccine, while the other had not. Dr. Warner captured these images as part of his study on the disease.

The smallpox vaccine holds historical significance as the first vaccine developed to combat a contagious disease.

In 1796, British doctor Edward Jenner demonstrated that an infection with the milder cowpox virus could provide immunity against the deadly smallpox virus.

Cowpox acted as a natural vaccine until the modern smallpox vaccine became available in the 20th century.

From 1958 to 1977, the World Health Organization led a global vaccination campaign that successfully eradicated smallpox, marking it as the only human disease to be completely eliminated.

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